The University of Dundee offers a BBSRC-funded 4-year PhD studentship to explore the role of poly(ADP-ribosylation) (PARylation) in neuronal function, particularly its impact on RNA biogenesis in aging neurons. This research focuses on understanding how PARylation modifies RNA-binding proteins, such as TDP-43, influencing mRNA splicing and neuronal survival. The PhD student will use advanced proteomics and transcriptomics techniques to investigate neuronal pathways relevant to neurodegenerative diseases and aging, contributing to critical research in these areas.